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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Recently Alzheimer’s Disease Neuroimaging Initiative (ADNI) observation has reported that MCI who has higher level of amyloid decline his cognitive ability faster than MCI who has a relative lower amyloid in his brain. However, in a normal patient’s brain in which the amyloid level was almost equal to that of an MCI patient’s brain, the cognitive ability was not at all declined. Consequently, a strong debate surrounds the differences between the normal, MCI, and AD patient’s brains regarding amyloid toxicity. It is rational that MCI has some unknown factors in which the toxicity is increased in the presence of amyloid, but a normal patient’s brain has no such unknown factors. Moreover, we observed that the neurodegenerative effect of homocysteic acid (HA) was significantly higher in MCI than that in a normal patient’s brain, and this HA toxicity was enhanced in the presence of amyloid. Therefore, it is highly possible that the previously mentioned unknown factor is HA. Tohru Hasegawa* 2016-04-12T18:56:06+05:30 2016-04-12T18:56:06+05:30 2016-04-12T18:56:06+05:30 5 Adobe InDesign CS6 (Windows) uuid:0dca8ba0-a81b-4da0-b11e-9d95c6ac256b xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:DB8F7E06B200E6118A77E41F5EB89CB3 proof:pdf xmp.iid:DA8F7E06B200E6118A77E41F5EB89CB3 xmp.did:24EDAEA39FC8E411BB3BED99DE70EEB1 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-04-12T18:56:06+05:30 Citation: Hasegawa T (2016) Homocysteic AcidMediates Amyloid Pathogenicity for CognitiveImpairment in Alzheimer’s Disease. J NeurolNeurobiol 2(3): doi http://dx.doi.org/10.16966/2379-7150.125 Tohru Hasegawa, Saga Women’s Junior College, Saga 840-8550,Japan, E-mail: ghf238134@leo.bbiq.jp Adobe PDF Library 10.0.1 False endstream endobj 227 0 obj <> endobj xref 0 798 0000000000 65535 f 0000229174 00000 n 0000229609 00000 n 0000229633 00000 n 0000238861 00000 n 0000238920 00000 n 0000239369 00000 n 0000239947 00000 n 0000240081 00000 n 0000248046 00000 n 0000248130 00000 n 0000248190 00000 n 0000248275 00000 n 0000248885 00000 n 0000249247 00000 n 0000249584 00000 n 0000250856 00000 n 0000266484 00000 n 0000266560 00000 n 0000267093 00000 n 0000267169 00000 n 0000267206 00000 n 0000304030 00000 n 0000304400 00000 n 0000304741 00000 n 0000304856 00000 n 0000304919 00000 n 0000305232 00000 n 0000305708 00000 n 0000305825 00000 n 0000305888 00000 n 0000306167 00000 n 0000306356 00000 n 0000306432 00000 n 0000306509 00000 n 0000306531 00000 n 0000306607 00000 n 0000306684 00000 n 0000306706 00000 n 0000306857 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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Recently Alzheimer’s Disease Neuroimaging Initiative (ADNI) observation has reported that MCI who has higher level of amyloid decline his cognitive ability faster than MCI who has a relative lower amyloid in his brain. However, in a normal patient’s brain in which the amyloid level was almost equal to that of an MCI patient’s brain, the cognitive ability was not at all declined. Consequently, a strong debate surrounds the differences between the normal, MCI, and AD patient’s brains regarding amyloid toxicity. It is rational that MCI has some unknown factors in which the toxicity is increased in the presence of amyloid, but a normal patient’s brain has no such unknown factors. Moreover, we observed that the neurodegenerative effect of homocysteic acid (HA) was significantly higher in MCI than that in a normal patient’s brain, and this HA toxicity was enhanced in the presence of amyloid. Therefore, it is highly possible that the previously mentioned unknown factor is HA. Tohru Hasegawa* 2016-04-12T18:56:06+05:30 2016-04-12T18:56:11+05:30 2016-04-12T18:56:11+05:30 5 Adobe InDesign CS6 (Windows) uuid:0a9592d3-c735-4b82-aab1-cd06856750aa xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:DB8F7E06B200E6118A77E41F5EB89CB3 proof:pdf xmp.iid:DA8F7E06B200E6118A77E41F5EB89CB3 xmp.did:24EDAEA39FC8E411BB3BED99DE70EEB1 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-04-12T18:56:06+05:30 Citation: Hasegawa T (2016) Homocysteic AcidMediates Amyloid Pathogenicity for CognitiveImpairment in Alzheimer’s Disease. J NeurolNeurobiol 2(3): doi http://dx.doi.org/10.16966/2379-7150.125 Tohru Hasegawa, Saga Women’s Junior College, Saga 840-8550,Japan, E-mail: ghf238134@leo.bbiq.jp Adobe PDF Library 10.0.1 False endstream endobj 227 0 obj <> endobj 799 0 obj <>/Metadata 226 0 R/Names 800 0 R/Outlines 193 0 R/PageMode/UseOutlines/Pages 225 0 R/StructTreeRoot 228 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 226 2 0000363208 00000 n 0000370271 00000 n 799 1 0000371587 00000 n trailer <<6008F90CB20EC4499B412B3DE91DE1C9>]/Prev 116>> startxref 371789 %%EOF