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Methods: We performed a retrospective case-control study in which medical records of lipodystrophic HIV-infected subjects and HIV-uninfected obese subjects with or without DM who were treated with liraglutide for 6 months were analyzed. A group of HIV-uninfected obese subjects served as controls. Subjects were separated into 4 groups: lipodystrophic HIV-infected subjects without DM (HIV-DM) (N=30), lipodystrophic HIVinfected subjects with DM (HIV+DM) (N=32), obese subjects without DM (obese-DM) (N=32), and obese subjects with DM (obese+DM) (N=53). Changes in body weight, blood pressure (BP), and glucose and lipid profiles were investigated over 6 months of liraglutide treatment. Results: Body weights were significantly reduced in all groups except HIV–DM. Glucose profile mainly improved in the obese+DM group. Liraglutide treatment of HIV–DM subjects tended to decrease low density lipoprotein cholesterol (LDL-C) and total cholesterol/ high density lipoprotein cholesterol (TC/HDL-C). In HIV+DM subjects, there was a tendency to lower BP, TC, and non-HDL-C in response to liraglutide. In obese-DM subjects, liraglutide tended to lower TC/HDL, triglyceride (TG), logTG/HDL, non-HDL-C and LDL-C. In obese-DM subjects, fasting blood glucose (FBG) and TC were significantly reduced. In obese+DM subjects, liraglutide treatment tended to lower BP, non-HDL-C, FBG, and logTG/HDL-C. Conclusions: Six months of liraglutide treatment of HIV-infected subjects resulted in weight loss, which was statistically significant only in subjects with diabetes; it also improved several metabolic abnormalities associated with HALS. © 2015 Saeedi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Ramesh Saeedi Parisa Dabirvaziri Negar Fouladi Nashta Masoud Yousefi SilviaGuillemi Julio Montaner Jiri Frohlich1 Marianne Harris and Greg Bondy GLP-1 analogue HIV Diabetes Body weight Metabolic abnormalities 2015-08-21T15:47:35+05:30 2015-08-21T15:47:36+05:30 2015-08-21T15:47:36+05:30 Adobe InDesign CS6 (Windows) uuid:748bc040-56d1-4aef-aa9d-06a4d24b7433 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:37DD4DBFEB47E511A84AB1CA0B3E79FE proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-08-21T15:47:35+05:30 xmp.iid:36DD4DBFEB47E511A84AB1CA0B3E79FE xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Saeedi R, Dabirvaziri P, Nashta NF,Yousefi M, Guillemi S, et al. (2015) Effects ofLiraglutide, a Glucagon-Like Peptide-1 Analogue,on Metabolic Abnormalities and Body Weightin HIV-infected Subjects with or without Type2 Diabetes. J HIV AIDS 1(2): http://dx.doi.org/10.16966/2380-5536.107 Objectives: To evaluate the effects of six-month liraglutide treatment on antiretroviral therapy (ART)-induced HIV-associated lipodystrophicsyndrome (HALS) including diabetes mellitus (DM), lipodystrophy, and dyslipidemia in HIV-infected subjects with and DM.Methods: We performed a retrospective case-control study in which medical records of lipodystrophic HIV-infected subjects and HIV-uninfectedobese subjects with or without DM who were treated with liraglutide for 6 months were analyzed. A group of HIV-uninfected obese subjects servedas controls. Subjects were separated into 4 groups: lipodystrophic HIV-infected subjects without DM (HIV-DM) (N=30), lipodystrophic HIVinfectedsubjects with DM (HIV+DM) (N=32), obese subjects without DM (obese-DM) (N=32), and obese subjects with DM (obese+DM) (N=53).Changes in body weight, blood pressure (BP), and glucose and lipid profiles were investigated over 6 months of liraglutide treatment.Results: Body weights were significantly reduced in all groups except HIV–DM. Glucose profile mainly improved in the obese+DM group.Liraglutide treatment of HIV–DM subjects tended to decrease low density lipoprotein cholesterol (LDL-C) and total cholesterol/ high densitylipoprotein cholesterol (TC/HDL-C). In HIV+DM subjects, there was a tendency to lower BP, TC, and non-HDL-C in response to liraglutide. Inobese-DM subjects, liraglutide tended to lower TC/HDL, triglyceride (TG), logTG/HDL, non-HDL-C and LDL-C. In obese-DM subjects, fastingblood glucose (FBG) and TC were significantly reduced. In obese+DM subjects, liraglutide treatment tended to lower BP, non-HDL-C, FBG, andlogTG/HDL-C.Conclusions: Six months of liraglutide treatment of HIV-infected subjects resulted in weight loss, which was statistically significant only insubjects with diabetes; it also improved several metabolic abnormalities associated with HALS. 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Methods: We performed a retrospective case-control study in which medical records of lipodystrophic HIV-infected subjects and HIV-uninfected obese subjects with or without DM who were treated with liraglutide for 6 months were analyzed. A group of HIV-uninfected obese subjects served as controls. Subjects were separated into 4 groups: lipodystrophic HIV-infected subjects without DM (HIV-DM) (N=30), lipodystrophic HIVinfected subjects with DM (HIV+DM) (N=32), obese subjects without DM (obese-DM) (N=32), and obese subjects with DM (obese+DM) (N=53). Changes in body weight, blood pressure (BP), and glucose and lipid profiles were investigated over 6 months of liraglutide treatment. Results: Body weights were significantly reduced in all groups except HIV–DM. Glucose profile mainly improved in the obese+DM group. Liraglutide treatment of HIV–DM subjects tended to decrease low density lipoprotein cholesterol (LDL-C) and total cholesterol/ high density lipoprotein cholesterol (TC/HDL-C). In HIV+DM subjects, there was a tendency to lower BP, TC, and non-HDL-C in response to liraglutide. In obese-DM subjects, liraglutide tended to lower TC/HDL, triglyceride (TG), logTG/HDL, non-HDL-C and LDL-C. In obese-DM subjects, fasting blood glucose (FBG) and TC were significantly reduced. In obese+DM subjects, liraglutide treatment tended to lower BP, non-HDL-C, FBG, and logTG/HDL-C. Conclusions: Six months of liraglutide treatment of HIV-infected subjects resulted in weight loss, which was statistically significant only in subjects with diabetes; it also improved several metabolic abnormalities associated with HALS. © 2015 Saeedi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Ramesh Saeedi Parisa Dabirvaziri Negar Fouladi Nashta Masoud Yousefi SilviaGuillemi Julio Montaner Jiri Frohlich1 Marianne Harris and Greg Bondy GLP-1 analogue HIV Diabetes Body weight Metabolic abnormalities 2015-08-21T15:47:35+05:30 2015-08-21T15:47:41+05:30 2015-08-21T15:47:41+05:30 Adobe InDesign CS6 (Windows) uuid:84582b85-7f50-4a6f-afa7-f54457f230c2 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:37DD4DBFEB47E511A84AB1CA0B3E79FE proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-08-21T15:47:35+05:30 xmp.iid:36DD4DBFEB47E511A84AB1CA0B3E79FE xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Saeedi R, Dabirvaziri P, Nashta NF,Yousefi M, Guillemi S, et al. (2015) Effects ofLiraglutide, a Glucagon-Like Peptide-1 Analogue,on Metabolic Abnormalities and Body Weightin HIV-infected Subjects with or without Type2 Diabetes. J HIV AIDS 1(2): http://dx.doi.org/10.16966/2380-5536.107 Objectives: To evaluate the effects of six-month liraglutide treatment on antiretroviral therapy (ART)-induced HIV-associated lipodystrophicsyndrome (HALS) including diabetes mellitus (DM), lipodystrophy, and dyslipidemia in HIV-infected subjects with and DM.Methods: We performed a retrospective case-control study in which medical records of lipodystrophic HIV-infected subjects and HIV-uninfectedobese subjects with or without DM who were treated with liraglutide for 6 months were analyzed. A group of HIV-uninfected obese subjects servedas controls. Subjects were separated into 4 groups: lipodystrophic HIV-infected subjects without DM (HIV-DM) (N=30), lipodystrophic HIVinfectedsubjects with DM (HIV+DM) (N=32), obese subjects without DM (obese-DM) (N=32), and obese subjects with DM (obese+DM) (N=53).Changes in body weight, blood pressure (BP), and glucose and lipid profiles were investigated over 6 months of liraglutide treatment.Results: Body weights were significantly reduced in all groups except HIV–DM. Glucose profile mainly improved in the obese+DM group.Liraglutide treatment of HIV–DM subjects tended to decrease low density lipoprotein cholesterol (LDL-C) and total cholesterol/ high densitylipoprotein cholesterol (TC/HDL-C). In HIV+DM subjects, there was a tendency to lower BP, TC, and non-HDL-C in response to liraglutide. Inobese-DM subjects, liraglutide tended to lower TC/HDL, triglyceride (TG), logTG/HDL, non-HDL-C and LDL-C. In obese-DM subjects, fastingblood glucose (FBG) and TC were significantly reduced. In obese+DM subjects, liraglutide treatment tended to lower BP, non-HDL-C, FBG, andlogTG/HDL-C.Conclusions: Six months of liraglutide treatment of HIV-infected subjects resulted in weight loss, which was statistically significant only insubjects with diabetes; it also improved several metabolic abnormalities associated with HALS. Adobe PDF Library 10.0.1 False endstream endobj 250 0 obj <> endobj 2646 0 obj <>/Metadata 249 0 R/Names 2647 0 R/Outlines 186 0 R/PageMode/UseOutlines/Pages 248 0 R/StructTreeRoot 251 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 249 2 0000481530 00000 n 0000492122 00000 n 2646 1 0000494446 00000 n trailer <]/Prev 116>> startxref 494650 %%EOF