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Fz:MP;HFaz,󽖏vjyowo+.v}=~׷_G~X~ۇ?}|_׿|y8)NqS8)~—w^YTJQqU+F/kW.*seǫrwRT{706*.zSSS$S$#'#'ִaddŀ7oz-z-z5S{*4i|b1& &bq.a o\Slb{oצҴa@m͚7kެyYl,cCntc̍17ƼzzbѸp m,bW^< قkπӋakӝ8s#צ³iR =v zG˓ 6"xRʕ7.*seQIk"Tn5XL}j3f ["5si\ذ0Ka"#YؔbS)?-"3B"PKS|z9qS~S|z B q\@M4hP@mPr@%w@}:|=IN 85| F9^/B Ё@t Ё@tUW^uxUW^uac6v`ہm}̌8_r#A:G9 QBt#0H駺7#uG)jQbȈ#-dddđuc3?c3ψ#:0É':pÉ':Y'8iI#Nq҈F4'8i3$r5zF#Qt?uG\Vd+2F#Qi9i2EQҗ*r F#KYJzWJyUwhMi/H{A ^ i/H{A ^ 8Xӆ 8 8x|PEA|P1c&97ȹA rns 97ȹA rns Ƭ 97ȹM|M]u ,_iJWڼJB۟8u?G9ϑsǨg5p0X` % 0Xp6 K,a0 `0b=0 `0! j2>5OMC؈5Yc@9>%ڀ * 0€ * 0€ * 0€ * 0€ * `C>[ 74pC 74pC7Df]cLFbh)Bh)Bh)Bh! f5CBjP3! f>vuͩ[rw-nyv˱[~rV·W2;)NqS-ZE-nwffw [k}/S{p [ݼsD-np [$0E-n1p [pG<EZ [ނO\h-mmk[XۢԶ%;Ws}(KiJVǒ]Kv^$^%YK9K]z7)OySRf;埙uC*>R񒊟?)KkSvN9w)LgRL3eϔRvKOʟRdKE8)NqSUޣ-ߢ-UE[v7Ht@u@v3pķu<8ߑ%&5?@8t+^_ 9)wf ?1G=+L9Kq8gA9Qk|stٳBcc,8/)K!l*fa=dOwThÁdrhZ ?G>+t49)M|#9LN/đIGGM:y5srt5m^<N?&ޒxK-'6QG:YML?PO> endobj 540 0 obj <> endobj 541 0 obj <>stream application/pdf Sudden Cardiac Death in Athletes: CurrentKnowledge and Newer Concepts Sudden Cardiac Death (SCD) is a rare but devastating event for the athlete’s family and for the community and occurs most often during sport activity. The prevalence of SCD ranges from 1 per 50,000 to 1 per 200,000 athletes per year. The risk seems higher in the athletes than in the non-athlete population, higher in men than in women and higher in competitive athletes than in non-professional athletes. The mechanisms of SCD was believed until recently to be the result of interactions of an underlying undetected heart disease with a number of acute and transient triggering factors. In athletes over 35 years of age, coronary artery disease is the dominant cause. In athletes younger than 35 years, congenital anomalies, inherited syndromes related to channelopathies are common associated conditions. Recently experimental evidence and clinical observations lead to believe that heavy and prolonged exercise may induce changes primarily in the right ventricular structure that mimic the familial arrhythmogenic right ventricular cardiomyopathy. The origin of these changes could not be ascribed to a genetic predisposition only and requires further investigation Preparticipation screening of athletes at risk and its cost-effectiveness is still the subject of debate because of the lack of evidence-based data. Detection of athletes at risk implies for detected individuals restriction regarding sports practice or /and competition. Despite these limitations, several scientific societies from both sides of the Atlantic have issued guidelines on the recommended work-up for detecting athletes at risk of SCD and on sports restriction which are discussed here. © 2015 Levy S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Samuel Levy1* Michael Peyrol2 and Pascal Sbragia2 Sudden death Athletes Sports Channelopathies Arrhythmogenic right ventricular cardiomyopathy 2015-09-16T18:41:04+05:30 2015-09-16T18:41:05+05:30 2015-09-16T18:41:05+05:30 5 Adobe InDesign CS6 (Windows) uuid:6dfde452-d44d-4f9a-ab3e-dc94bba68099 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:BF26800F745CE511BED0B1A172F5A27E proof:pdf xmp.iid:BE26800F745CE511BED0B1A172F5A27E xmp.did:9A7BCE2A86C8E411A9F7BE0811E790A6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-09-16T18:41:04+05:30 Citation: Levy S, Peyrol M, Sbragia P (2015)Sudden Cardiac Death in Athletes: Currentknowledge and Newer Concepts. J Hear Health1 (3): doi http://dx.doi.org/10.16966/2379-769X.111 Samuel Levy, Professor of Cardiology, Aix-Marseille Université, Schoolof Medicine, Marseille, France, Tel: 336 74 00 98 46, 33 953 677 241; E-mail: samuel@samuellevy.com Adobe PDF Library 10.0.1 False endstream endobj 542 0 obj <> endobj xref 0 1853 0000000000 65535 f 0000244207 00000 n 0000244662 00000 n 0000244686 00000 n 0000254553 00000 n 0000254612 00000 n 0000255068 00000 n 0000255091 00000 n 0000255225 00000 n 0000264884 00000 n 0000264968 00000 n 0000265028 00000 n 0000265498 00000 n 0000265523 00000 n 0000265659 00000 n 0000273846 00000 n 0000273960 00000 n 0000274045 00000 n 0000274105 00000 n 0000274576 00000 n 0000275351 00000 n 0000275487 00000 n 0000283759 00000 n 0000283844 00000 n 0000283904 00000 n 0000284349 00000 n 0000285246 00000 n 0000285382 00000 n 0000292968 00000 n 0000293053 00000 n 0000293113 00000 n 0000293198 00000 n 0000293810 00000 n 0000294173 00000 n 0000294510 00000 n 0000295787 00000 n 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The prevalence of SCD ranges from 1 per 50,000 to 1 per 200,000 athletes per year. The risk seems higher in the athletes than in the non-athlete population, higher in men than in women and higher in competitive athletes than in non-professional athletes. The mechanisms of SCD was believed until recently to be the result of interactions of an underlying undetected heart disease with a number of acute and transient triggering factors. In athletes over 35 years of age, coronary artery disease is the dominant cause. In athletes younger than 35 years, congenital anomalies, inherited syndromes related to channelopathies are common associated conditions. Recently experimental evidence and clinical observations lead to believe that heavy and prolonged exercise may induce changes primarily in the right ventricular structure that mimic the familial arrhythmogenic right ventricular cardiomyopathy. The origin of these changes could not be ascribed to a genetic predisposition only and requires further investigation Preparticipation screening of athletes at risk and its cost-effectiveness is still the subject of debate because of the lack of evidence-based data. Detection of athletes at risk implies for detected individuals restriction regarding sports practice or /and competition. Despite these limitations, several scientific societies from both sides of the Atlantic have issued guidelines on the recommended work-up for detecting athletes at risk of SCD and on sports restriction which are discussed here. © 2015 Levy S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Samuel Levy1* Michael Peyrol2 and Pascal Sbragia2 Sudden death Athletes Sports Channelopathies Arrhythmogenic right ventricular cardiomyopathy 2015-09-16T18:41:04+05:30 2015-09-16T18:41:11+05:30 2015-09-16T18:41:11+05:30 5 Adobe InDesign CS6 (Windows) uuid:f7491f20-4cbb-48bf-a256-96dc8368f62a xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:BF26800F745CE511BED0B1A172F5A27E proof:pdf xmp.iid:BE26800F745CE511BED0B1A172F5A27E xmp.did:9A7BCE2A86C8E411A9F7BE0811E790A6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-09-16T18:41:04+05:30 Citation: Levy S, Peyrol M, Sbragia P (2015)Sudden Cardiac Death in Athletes: Currentknowledge and Newer Concepts. J Hear Health1 (3): doi http://dx.doi.org/10.16966/2379-769X.111 Samuel Levy, Professor of Cardiology, Aix-Marseille Université, Schoolof Medicine, Marseille, France, Tel: 336 74 00 98 46, 33 953 677 241; E-mail: samuel@samuellevy.com Adobe PDF Library 10.0.1 False endstream endobj 542 0 obj <> endobj 1854 0 obj <>/Metadata 541 0 R/Names 1855 0 R/Outlines 478 0 R/PageMode/UseOutlines/Pages 540 0 R/StructTreeRoot 543 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 541 2 0000490379 00000 n 0000498581 00000 n 1854 1 0000500564 00000 n trailer <<2A4F8DB83303EE40AC65DA0CF551988B>]/Prev 116>> startxref 500768 %%EOF