教育

傳記

Ting-Chao周出生在台灣,收到耶魯大學藥理學博士學位和博士後獎學金從約翰·霍普金斯大學醫學院的。他加入了紀念斯隆-凱特琳癌症中心(MSKCC)和成為一個成員,和康奈爾大學藥理學教授1988年醫學科學研究生院。他是中國醫學科學院的名譽教授,並在5所大學客座教授。他從2013年6月MSKCC退休,創立了PD科學,LLC(美國)促進量化索引pharmaco-dynamics econo-green生物醫學研究與開發和科學管理事務和法律定義。周博士與25145年發表的326篇論文引用(穀歌學術搜索)h指數為67。他介紹了Median-Effect質量作用定律理論》(1976)和聯合組合指數定理,CalcuSyn和CompuSyn軟件。他的理論引入CI方法和軟件(周TC & Talalay酶Regul 22:27-55。p ., 1984)已經被引用了4921次超過741生物醫學期刊。周博士是發明家/ 39我們專利的發明者之一,大多數抗癌藥物。他提出現代理化和數學的解釋主要概念在古代東方哲學。

研究的興趣

生物化學與分子生物學;細胞生物學;免疫學;傳染病;生命科學和生物醫學-;數學方法在社會科學;腫瘤;藥理學和藥房;哲學;熱力學; Transplantation.

科學活動:

教學經驗

榮譽、獎勵和會員

出版物

1. Creasey,西澳和周,t - C。秋水仙堿的綁定肉瘤180個細胞。物化學。雜誌。17:477 - 481,1968。(如:4.65)
2. 周,t - C。和李,彭譯葶。整個分離眼鏡蛇毒對交感神經節的傳播。歐元。j .雜誌。8:326 - 330,1969。(如:2.68)
3. 周,t - C。L -天冬酰胺生物合成及其控製。一篇論文提交給研究生院參加耶魯大學的博士學位(1970年),美國版權(1972)。
4. 周,t - C。Handschumacher,右眼生產L -天冬酰胺的腫瘤細胞和天門冬素類似物的影響。物化學。1972年雜誌。21:39 - 48。(如:4.65)
5. 周,t - C。多個基質-多個產品的組合分析酶反應。j .係統結構。生物35:285 - 297,1972。(如:2.30
6. 周,t - C。Talalay, p S -腺苷甲硫氨酸合成的機製純化製備麵包師的酵母。生物化學11:1065 - 1073,1972。(如:6.58)
7. 周,t - C。和Lombardini J.B. ATP快速測定過程:L -蛋氨酸S - adenosyl轉移酶。Biochim。Biophys。Acta 276:399 - 406, 1972。(如:3.37)
8. Lombardini, J.B.周,t - C。Talalay, p .監管的性質三磷酸腺苷- L -蛋氨酸年代adenosyl——鼠肝轉移酶。物化學。1973年j . 135:43 - 57。(如:4.28)
9. 周,t - C。,and Talalay, P. Inhibition of ATP: L‑methionine S‑adenosyltransferase of bakers' yeast by structural analogues of ATP. Biochim. Biophys. Acta 321:467‑474, 1973. (IF: 3.37)
10. 周,t - C。抑製常數之間的關係和部分抑製酶-催化反應與反應物的不同數量,不同的反應機製,不同類型的抑製機製。摩爾。雜誌10:235 - 247。1974年。(如:4.12)
11. 周,t - C。一般程序確定中等劑量-效應的雙對數變換的劑量-反應關係。美聯儲,Proc。34:228 - 228, 1975。
12. 周,蘇耿賦。克拉克森,b . d和飛利浦f·s·阿糖胞苷的代謝(Ara-C)體外正常和白血病的血液和骨髓。Proc。。Assoc。癌症研究》16:79 - 79年,1975年。
13. 周,t - C。,Hutchinson, D.J., Schmid, F.A. and Philips, F.S. Metabolism and selective effect of 1‑b‑D‑arabinofuranosyl-cytosine in L1210 and host tissues in vivo. Cancer Res. 35:225‑236, 1975. (IF: 9.28)
14. 周,t - C。Talalay, p .多個抑製和isobol酶動力學係統:通用方程的推導。美聯儲Proc。35:284, 1976。
15. 周,t - C。,Hutchinson, D.J., Schmid, F.A. and Philips, F.S. Occurrence of deaminated monophosphate nucleotide in extra‑ cellular sites after giving arabinofuranosylcytosine to mice. Ann. N.Y. Acad. Sci. 255:287‑291, 1975. (IF: 4.31)
16. 飛利浦F.S.周,t - C。,Hutchinson, D.J., Schmid, F.A. and Sternberg, S.S. Selective toxicity and chemotherapeutic efficacy. In Pharmacological Basis of Cancer Chemotherapy, pp.469‑484, Williams & Williams, Baltimore, 1975.
17. 周,t - C。米歇利斯- Menten派生和屬性類型和希爾類型方程配體供參考。j .係統結構。生物59:253 - 276,1976。(如:2.30)
18. 周,t - C。配體結合位點的測定可用性-穩定狀態係統。j .係統結構。生物65:345 - 356,1977。(如:2.30)
19. 周,t - C。比較質量-行動的法律與冪律,概率單位法和分對數低劑量-效應分析。藥理學家19:165 - 165,1977。
20. 周,t - C。比達爾,P。and Philips, F.S. Comparison of tissue distribution and fate of 2,2'‑anhydro‑1‑b‑D‑arabinofuranosyl ‑5‑fluorocytosine (AAFC) and 1‑b‑D‑arabinofuranosyl‑5‑fluoro-cytosine (AFC) in rats. Cancer Treatment Rep. 61:617‑624, 1977.
21. 周,t - C。,Coulter, A.W., Lombardini, J.B., Sufrin, J.B. and Talalay, P. The enzymatic synthesis of S‑adenosyl‑L‑ methionine: Mechanisms and inhibition. In The Biochemistry of Adenosylmethionine: Chemistry, Metabolism and Biological Roles,, pp. 18‑36, Columbia University Press, 1977.
22. 周,t - C。Talalay, p .一個簡單的通用方程的分析多米歇利斯- Menten動力學係統的禁忌。生物。化學252:6438 - 6442,1977。(如:6.36)
23. 周,t - C。阿爾林,Z。,克拉克森,B。C. and Philips, F.S. Metabolism of 1‑b‑D‑arabinofuranosylcytosine in human leukemic cells. Cancer Res. 37:3561‑3570, 1977. (IF: 9.28)
24. 克拉克森,B。、油炸、J。,周,t - C。衝突,。,Ferguson, R., Sullivan, S., Kitahara, T. and Oyama, A. Duration of the dormant state in an established cell line of human hematopoietic cells. Cancer Res. 37:4506‑4522, 1977. (IF: 9.28)
25. 周,t - C。,Burchenal, J.H., Fox, J.J., Watanabe, K.A., Chu, C.K. and Philips, F.S. Metabolism and effects of 5‑(b‑D‑ribofuranosyl) isocytosine in P815 cells. Cancer Res. 39:720‑728, 1979. (IF: 9.28)
26. 周,t - C。分析特定年齡死亡率方程-中值不同的原因的影響。美聯儲,Proc。37:882 - 882, 1978。
27. 周,t - C。Talalay, p .一般方程為多個抑製米歇利斯- Menten和希爾動力係統由相互排斥和非獨家的抑製劑。美聯儲,Proc。38:645 - 645, 1979。
28. 周,蘇耿賦。比較低劑量慢性接觸後致癌物質的量效關係和大劑量單注:median-effect原理的分析。致癌1:203 - 213,1980。(如:5.38)
29. 周,t - C。和米勒,D.G.兩參數分析癌症發病率趨勢的方法。第四屆年會。Soc。上一頁。腫瘤防治雜誌。,Chicago, Ill. March 6‑7,. p.10-10, 1980.
30. 丘鷸,T.M.周,t - C。棕褐色,教學樓。,Sternberg, S.S., Philips, F.S., Young, C.W. and Burchenal, J.H. Biochemical, pharmacological, and phase I clinical evaluation of pseudoisocytidine. Cancer Res. 40:4243‑4249, 1980. (IF: 9.28)
31. Warrell r。小周,t - C。,戈登,C。棕褐色,C。,Roberts, J., Sternberg, S.S., Philips, F.S. and Young, C.W. Phase I evaluation of succinylated acinetobacter glutaminase‑ asparaginase in adults. Cancer Res. 40:4546‑4551, 1980. (IF: 9.28)
32. 周,t - C。致癌風險評估的質量-訴訟法原則:應用大規模長期飼養試驗2 - acetylaminofluorene(2 -空軍聯隊)。Proc。。Assoc。癌症研究》22:141 - 141,1981。
33. 周,t - C。Talalay, p廣義方程分析抑製劑米歇利斯- Menten和高階動力學係統的兩個或兩個以上相互排斥和非獨家的抑製劑。四。學生物化學j。115:207 - 216, 1981。(如:3.26)
34. 渡邊·,Reichman, U., Fox, J.J. and Chou, T.‑C. Substrate- specificity and mechanism of action of cytidine deaminase of monkey plasma and mouse kidney. Nucleoside CXIX. Chemico‑Biol. Interactions 37:41‑54, 1981.
35. 周,t - C。,Feinberg, A., Grant, A.J., Vidal, P., Reichman, U., Watanabe, K.A., Fox, J.J. and Philips, F.S. Pharmacological disposition and metabolic fate of 2'‑fluoro‑5‑iodo‑1‑b‑D‑arabinofuranosylcytosine in mice and rats. Cancer Res. 41:3336‑ 3342, 1981. (IF: 9.28)
36. 周,t - C。,Burchenal, J.H., Schmid, F.A., Braun, T.J., Su, T.L., Watanabe, K.A., Fox, J.J., and Philips, F.S. Biochemical effects of 2'‑fluoro‑5‑methyl‑1‑b‑D‑arabino- furanosyluracil and 2'‑fluoro‑5‑iodo‑1‑b‑D‑arabino- furanosylcytosine in mouse leukemic cells sensitive and resistant to 1-b-D-arabinosylcytosine. Cancer Res. 42:3957‑3963, 1982. (IF: 9.28)
37. 出納員,M.N.,股票,C。鮑伊,M。,周,t - C。,and Budinger, J.M. Therapy of 7,12-dimethylbenz(A)anthrace3ne-‑induced rat mammary carcinomas with combinations of 5‑fluorouracil and 2‑a‑methyldihydro-testos-terone propionate. Cancer Res. 42:4408‑4412, 1982. (IF: 9.28)
38. 格蘭特,正當,Feinberg, A., Chou, T.‑C., Watanabe, K.A., Fox, J.J., and Philips, F.S. Incorporation of 2'‑fluoro‑5‑ iodo‑1‑b‑D‑ arabinofuranosylcytosine into DNA of neoplastic and normal mammalian tissues. Biochem. Pharmacol. 31:1103‑1108, 1982. (IF: 4.65)
39. Burchenal, J.J.周,t - C。Lokys, L。,Smith, R.S., Watanabe, K.A., Su, T.L., and Fox, J.J. Activity of 2'‑fluoro‑5‑methyl‑ arauracil against mouse leukemias sensitive and resistant to 1-b-D-arabinosylcytosine. Cancer Res. 42:2598‑2600, 1982. (IF: 9.28)
40. Warrell r。,J。,Arlin, Z.A., Gee, T.S., Chou, T.‑C., Roberts, J., and Young, C.W. Clinical evaluation of succinylated acinetobacter glutaminase‑asparaginase in adult leukemia. Cancer Treat. Rep. 66:1479‑1485, 1982.
41. 周,t - C。和Talalay、p分析結合藥物的效果:一個新的看一個非常古老的問題。趨勢雜誌。Sci 4:450 - 454, 1983。(如:13.05)
42. 周,t - C。,Schmidt, F.A., Feinberg, A., Philips, F.S., and Han, J. Uptake, initial effects, and chemotherapeutic efficacy of harringtonine in murine leukemic cells sensitive and resistant to vincristine and other chemotherapeutic agents. Cancer Res. 43:3074‑3079, 1983. (IF: 9.28)
43. Kolassa, N。,Paterson, A.R.P., and Chou, T.‑C. Modification of nitro‑benzylthioinosine 5'‑monophosphate of pseudoisocytosine pharmacokinetics in mice and rats through inhibition of membrane transport. Cancer Treat. Rep. 67:51‑58, 1983.
44. 李,教學樓。,Chello, P.L., Chou, T.‑C., Templeton, M.A., and Parham, J.C. Synthesis of an N‑aminopyrazinonium analog of cytidine. J. Med. Chem. 26:283‑285, 1983. (IF: 5.48)
45. Steckel, J。,Robert, J., Philips, F.S., and Chou, T.‑C. Kinetic properties and inhibition of acinetobacter glutaminase‑ asparaginase. Biochem. Pharmacol. 32:971‑977, 1983. (IF: 4.65)
46. 飛利浦F.S.,Feinberg, A., Chou, T.‑C., Vidal, P.M., Su, T.L., Watanabe, K.A., and Fox, J.J. Distribution, metabolism, and excretion of 1‑(2‑fluoro‑2‑deoxy‑b‑D- arabinofuranosyl)‑thymine and 1‑(2‑fluoro‑2‑deoxy‑b‑D‑ arabinofuranosyl)‑5‑iodo‑cytosine. Cancer Res. 43: 3619‑3627, 1983. (IF: 9.28)
47. Blumenreich,碩士周,t - C。Andreeff, M。淡水河穀,K。,克拉克森,B。D., and Young, C.W. Thymidine as a kinetic and biochemical modulator of 1‑b‑D‑arabinofuranosylcytosine in human acute nonlymphocytic leukemia. Cancer Res. 44:825‑830, 1984. (IF: 9.28)
48. Blumenreich,碩士丘鷸,T.M.Andreeff, M。,Hiddemann, W., Chou, T.‑C., Vale, K., O'Hehir, M., Clarkson, B., and Young, C.W. Effect of very high‑dose thymidine infusion on leukemia and lymphoma patients. Cancer Res. 44:2203‑2207, 1984. (IF: 9.28)
49. 周,J。,周,t - C。Talalay, p .保護改進的實驗設計,實驗動物的廣義方程和計算機分析。美聯儲,Proc。43:576 - 576, 1984。
50. 周,t - C。洛佩茲,C。,Colacino, J.M., Feinberg, A., Watanabe, K.A., Fox, J.J., and Philips, F.S. Metabolic competition studies of 2'‑fluoro‑5‑iodo‑1‑b‑D‑arabino- furanosylcytosine in Vero cells and herpes simplex type 1‑infected Vero cells. Mol. Pharmacol. 26:587‑593, 1984. (IF: 4.12)