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In order to screen out the various factors during liposome formulation development, Plackett Burman screening design was applied. Three formulation variables and eight process variables were identified and one factor plot was used to predict the response. The present study was aimed at identifying the important factors among the various factors, which could attribute to obtain highest drug entrapment during formulation of flexible liposomes. Results obtained proved that application of a screening design such as Plackett-Burman design efficiently identified the most significant factors. Identified significant factors were further optimized using Central Composite Design using the software Design Expert v 6.0. Three optimal solutions suggested by the design were characterized for entrapment efficiency, particle size, zeta potential and microscopical analysis. Results demonstrate the feasibility of applying statistical designs in the development of flexible liposomes of methotrexate. © 2016 Vanaja K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Vanaja K1 2* Shobha Rani RH1 Narendra C2 2016-03-30T20:45:01+05:30 2016-03-30T20:45:03+05:30 2016-03-30T20:45:03+05:30 4 Adobe InDesign CS6 (Windows) uuid:4b62eadf-247a-41a7-9f4e-55ca3e36bde1 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:E6E029278AF6E511AB35E0E5A57EDDC6 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-03-30T20:45:01+05:30 xmp.iid:E5E029278AF6E511AB35E0E5A57EDDC6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Citation: Vanaja K, Shobha Rani RH, NarendraC (2016) Application of Statistical Designs in theFormulation of Lipid Carriers of Methotrexate. J DrugRes Dev 2(1): doi http://dx.doi.org/10.16966/2470-1009.113 Vanaja K, Assistant Professor, Visveswarapura Institute of PharmaceuticalSciences, BSK II stage, Bangalore, India, E-mail: vanaja_ceutics@yahoo.com Adobe PDF Library 10.0.1 False endstream endobj 347 0 obj <> endobj xref 0 2524 0000000000 65535 f 0000248438 00000 n 0000248955 00000 n 0000248979 00000 n 0000259508 00000 n 0000259576 00000 n 0000259663 00000 n 0000263659 00000 n 0000263915 00000 n 0000264080 00000 n 0000264103 00000 n 0000264410 00000 n 0000280449 00000 n 0000280716 00000 n 0000280776 00000 n 0000281299 00000 n 0000281324 00000 n 0000281459 00000 n 0000292414 00000 n 0000292499 00000 n 0000292559 00000 n 0000293118 00000 n 0000293143 00000 n 0000293278 00000 n 0000301928 00000 n 0000301983 00000 n 0000333969 00000 n 0000334006 00000 n 0000335231 00000 n 0000338527 00000 n 0000338612 00000 n 0000338672 00000 n 0000339329 00000 n 0000339354 00000 n 0000339489 00000 n 0000369110 00000 n 0000369380 00000 n 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65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF 346 0 obj <>stream application/pdf Application of Statistical Designs in the Formulationof Lipid Carriers of Methotrexate Methotrexate (MTX) being the widely used biologic agent is used to treat severe and/or disabling psoriasis but precipitates various side effects on oral therapy. Encapsulating methotrexate in flexible liposomes for delivery through skin could lead to better therapeutic action and reduce side effects. In order to screen out the various factors during liposome formulation development, Plackett Burman screening design was applied. Three formulation variables and eight process variables were identified and one factor plot was used to predict the response. The present study was aimed at identifying the important factors among the various factors, which could attribute to obtain highest drug entrapment during formulation of flexible liposomes. Results obtained proved that application of a screening design such as Plackett-Burman design efficiently identified the most significant factors. Identified significant factors were further optimized using Central Composite Design using the software Design Expert v 6.0. Three optimal solutions suggested by the design were characterized for entrapment efficiency, particle size, zeta potential and microscopical analysis. Results demonstrate the feasibility of applying statistical designs in the development of flexible liposomes of methotrexate. © 2016 Vanaja K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Vanaja K1 2* Shobha Rani RH1 Narendra C2 2016-03-30T20:45:01+05:30 2016-03-30T20:45:07+05:30 2016-03-30T20:45:07+05:30 4 Adobe InDesign CS6 (Windows) uuid:f6600577-cbff-434f-a619-ce6f2dda4d1e xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:E6E029278AF6E511AB35E0E5A57EDDC6 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-03-30T20:45:01+05:30 xmp.iid:E5E029278AF6E511AB35E0E5A57EDDC6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Citation: Vanaja K, Shobha Rani RH, NarendraC (2016) Application of Statistical Designs in theFormulation of Lipid Carriers of Methotrexate. J DrugRes Dev 2(1): doi http://dx.doi.org/10.16966/2470-1009.113 Vanaja K, Assistant Professor, Visveswarapura Institute of PharmaceuticalSciences, BSK II stage, Bangalore, India, E-mail: vanaja_ceutics@yahoo.com Adobe PDF Library 10.0.1 False endstream endobj 347 0 obj <> endobj 2525 0 obj <>/Metadata 346 0 R/Names 2526 0 R/Outlines 255 0 R/PageMode/UseOutlines/Pages 345 0 R/StructTreeRoot 348 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 346 2 0000837441 00000 n 0000844993 00000 n 2525 1 0000846614 00000 n trailer <<0C3AA385D9BC174980EAB9C1CBD13CF0>]/Prev 116>> startxref 846818 %%EOF