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Various novel approaches are being explored including antimutagen, efflux inhibitors etc which can act as adjuvant therapy. But there is still need to develop real anti-mycobacterial drug. This research reports small molecule anti-infectives which are specifically potent against several strains and isolates of TB. The hit compound 7f has also proved to be active against almost 25 clinical isolates comparable to marketed anti-TB agents. © 2015 Mahajan NS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. N. S. Mahajan1*and S. C. Dhawale2 MDR-TB M. Tuberculosis Pyridine Oxadiazole Resistance 2016-01-04T10:49:33+05:30 2016-01-04T10:49:35+05:30 2016-01-04T10:49:35+05:30 4 Adobe InDesign CS6 (Windows) uuid:5c8a2067-0793-4d64-b4cc-f876f803a4b3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:E83E97BDA2B2E51197DBF5561168FC19 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-01-04T10:49:33+05:30 xmp.iid:93E92F63A2B2E51197DBF5561168FC19 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Citation: Mahajan NS, Dhawale SC (2015)Design, Synthesis and Evaluation of LinkedPyridinyl-Oxadiazoles as Treatment of XDR andMDR Tuberculosis-Part II. J Drug Res Dev 1(2):http://dx.doi.org/10.16966/jdrd.109 N. S. Mahajan, Department of Pharmaceutical Chemistry, Adarsh Collegeof Pharmacy, Bhavani Nagar, Kundal Road, Maharashtra, India, E-mail: nsmahajanns@gmail.com Adobe PDF Library 10.0.1 False endstream endobj 260 0 obj <> endobj xref 0 3422 0000000000 65535 f 0000270597 00000 n 0000271104 00000 n 0000271128 00000 n 0000283154 00000 n 0000283213 00000 n 0000283669 00000 n 0000283692 00000 n 0000283826 00000 n 0000297138 00000 n 0000297222 00000 n 0000297282 00000 n 0000297755 00000 n 0000297780 00000 n 0000297916 00000 n 0000310441 00000 n 0000310526 00000 n 0000310586 00000 n 0000311094 00000 n 0000311119 00000 n 0000311255 00000 n 0000324636 00000 n 0000325676 00000 n 0000325979 00000 n 0000332528 00000 n 0000332565 00000 n 0000332650 00000 n 0000332710 00000 n 0000333209 00000 n 0000333594 00000 n 0000333730 00000 n 0000343259 00000 n 0000343344 00000 n 0000343404 00000 n 0000343822 00000 n 0000343975 00000 n 0000344111 00000 n 0000345688 00000 n 0000345773 00000 n 0000345833 00000 n 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0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF 259 0 obj <>stream application/pdf Design, Synthesis and Evaluation of LinkedPyridinyl-Oxadiazoles as Treatment of XDR andMDR Tuberculosis-Part II Recently, Mycobacterium tuberculosis (MTB) strains have transformed from about to be eradicated to most resistant microbe, thank to Multidrug resistant (MDR) and extremely drug resistant (XDR) MTB. Various novel approaches are being explored including antimutagen, efflux inhibitors etc which can act as adjuvant therapy. But there is still need to develop real anti-mycobacterial drug. This research reports small molecule anti-infectives which are specifically potent against several strains and isolates of TB. The hit compound 7f has also proved to be active against almost 25 clinical isolates comparable to marketed anti-TB agents. © 2015 Mahajan NS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. N. S. Mahajan1*and S. C. Dhawale2 MDR-TB M. Tuberculosis Pyridine Oxadiazole Resistance 2016-01-04T10:49:33+05:30 2016-01-04T10:49:47+05:30 2016-01-04T10:49:47+05:30 4 Adobe InDesign CS6 (Windows) uuid:bf42fa95-e0f4-4d7a-b0e5-ef668874618b xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:E83E97BDA2B2E51197DBF5561168FC19 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-01-04T10:49:33+05:30 xmp.iid:93E92F63A2B2E51197DBF5561168FC19 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Citation: Mahajan NS, Dhawale SC (2015)Design, Synthesis and Evaluation of LinkedPyridinyl-Oxadiazoles as Treatment of XDR andMDR Tuberculosis-Part II. J Drug Res Dev 1(2):http://dx.doi.org/10.16966/jdrd.109 N. S. Mahajan, Department of Pharmaceutical Chemistry, Adarsh Collegeof Pharmacy, Bhavani Nagar, Kundal Road, Maharashtra, India, E-mail: nsmahajanns@gmail.com Adobe PDF Library 10.0.1 False endstream endobj 260 0 obj <> endobj 3423 0 obj <>/Metadata 259 0 R/Names 3424 0 R/Outlines 192 0 R/PageMode/UseOutlines/Pages 258 0 R/StructTreeRoot 261 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 259 2 0000544791 00000 n 0000551909 00000 n 3423 1 0000552913 00000 n trailer <]/Prev 116>> startxref 553117 %%EOF