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Cellulite in different stages of severity affects up to 98% of post pubertal women. The initial phase of cellulite is characterized by subdermal tissue oedema with fluids retention. A new topical product with draining action (HTC) containing escine, beta-sytosterols, caffeine and hypertonic sodium chloride has been recently developed. In an experimental human skin model study, HTC has demonstrated to be able to drain from the skin a water amount of 5% of its weight when applied over the skin specimen. © 2017 Milani M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Massimo Milani1* and Mario Puviani2 Lipodystrophy Randomized controlled trial 2018-01-06T14:01:17+05:30 2018-01-06T14:01:18+05:30 2018-01-06T14:01:18+05:30 Adobe InDesign CS6 (Windows) uuid:94271a76-9fa5-4d27-bd87-6839da1d02b2 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:3EE722EDBBF2E7119687C27756AD8C88 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-01-06T14:01:17+05:30 xmp.iid:3DE722EDBBF2E7119687C27756AD8C88 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Citation: Milani M, Puviani M (2017) Clinical Efficacyof a New Hypertonic Draining Cream in the Treatmentof Cellulite: A Randomized, Double Blind Right-vs-Left Placebo-Controlled Trial. J Clin Cosmet Dermatol1(1): doi http://dx.doi.org/10.16966/jccd.109 Massimo Milani, Medical Director, Difa Cooper Medical DepartmentCaronno Pertusella (VA), Via Milano 160, Italy, E-mail: Massimo.Milani@difacooper.com Adobe PDF Library 10.0.1 False endstream endobj 140 0 obj <> endobj xref 0 594 0000000000 65535 f 0000201878 00000 n 0000202398 00000 n 0000202422 00000 n 0000212061 00000 n 0000213277 00000 n 0000213562 00000 n 0000213891 00000 n 0000242878 00000 n 0000243132 00000 n 0000279931 00000 n 0000279967 00000 n 0000316767 00000 n 0000316804 00000 n 0000316864 00000 n 0000317316 00000 n 0000317551 00000 n 0000317687 00000 n 0000323023 00000 n 0000323108 00000 n 0000323168 00000 n 0000323253 00000 n 0000323863 00000 n 0000324225 00000 n 0000324562 00000 n 0000325851 00000 n 0000341323 00000 n 0000341400 00000 n 0000341437 00000 n 0000345692 00000 n 0000346062 00000 n 0000346188 00000 n 0000346539 00000 n 0000346565 00000 n 0000346943 00000 n 0000347321 00000 n 0000347679 00000 n 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0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <<6E857DDED2B8CE469A9A8E299155DA54>]>> startxref 116 %%EOF 139 0 obj <>stream application/pdf Clinical Efficacy of a New Hypertonic DrainingCream in the Treatment of Cellulite: A Randomized,Double Blind Right-vs-Left Placebo-Controlled Trial Cellulite (gynoid lipodystrophy) is a common skin alteration representing mainly a cosmetic concern rather than a pathological condition. Cellulite in different stages of severity affects up to 98% of post pubertal women. The initial phase of cellulite is characterized by subdermal tissue oedema with fluids retention. A new topical product with draining action (HTC) containing escine, beta-sytosterols, caffeine and hypertonic sodium chloride has been recently developed. In an experimental human skin model study, HTC has demonstrated to be able to drain from the skin a water amount of 5% of its weight when applied over the skin specimen. © 2017 Milani M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Massimo Milani1* and Mario Puviani2 Lipodystrophy Randomized controlled trial 2018-01-06T14:01:17+05:30 2018-01-06T14:01:22+05:30 2018-01-06T14:01:22+05:30 Adobe InDesign CS6 (Windows) uuid:226d2e58-a00a-4d8c-b60b-584e359ae628 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:3EE722EDBBF2E7119687C27756AD8C88 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-01-06T14:01:17+05:30 xmp.iid:3DE722EDBBF2E7119687C27756AD8C88 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Citation: Milani M, Puviani M (2017) Clinical Efficacyof a New Hypertonic Draining Cream in the Treatmentof Cellulite: A Randomized, Double Blind Right-vs-Left Placebo-Controlled Trial. J Clin Cosmet Dermatol1(1): doi http://dx.doi.org/10.16966/jccd.109 Massimo Milani, Medical Director, Difa Cooper Medical DepartmentCaronno Pertusella (VA), Via Milano 160, Italy, E-mail: Massimo.Milani@difacooper.com Adobe PDF Library 10.0.1 False endstream endobj 140 0 obj <> endobj 595 0 obj <>/Metadata 139 0 R/Names 596 0 R/Outlines 97 0 R/PageMode/UseOutlines/Pages 138 0 R/StructTreeRoot 141 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 139 2 0000385925 00000 n 0000392978 00000 n 595 1 0000394025 00000 n trailer <]/Prev 116>> startxref 394226 %%EOF