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The stalling of replication forks is symptomatic of mechanistic pathways that significantly induce the creation and progression of double strand breaks inherent to physiologic meiotic pathways. It is further to the disruption of pathways of double strand break repair that the DNA synthesis and cell cycling events further establish the importance of aberrant genetic diversity in tumorigenesis and progression. Synthetic viability, in contrast to synthetic lethality, may potentially aid in the understanding of several steps in the malignant transformation process. It would appear necessary to associate synthetic viability with an essential contrasting process of synthetic lethality, although up to date synthetic viability has been insufficiently emphasized in the discussions regarding the mechanics of carcinogenesis. © 2017 Agius LM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Lawrence M Agius* Homologous recombination Synthetic lethality Carcinogenesis DNA synthesis Cell cycling 2017-04-12T16:45:28+05:30 2017-04-12T16:45:29+05:30 2017-04-12T16:45:29+05:30 4 Adobe InDesign CS6 (Windows) uuid:5a50f4b9-0247-4504-b2a4-337c8eb6dc3a xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:16B8B650711FE7118F62BAC458F0A393 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2017-04-12T16:45:28+05:30 xmp.iid:15B8B650711FE7118F62BAC458F0A393 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Citation: Agius LM (2017) Physiologically AberrantHomologous Recombination Coupled to SyntheticLethality and especially Viability Pathways inCarcinogenesis within Contextually Active DNASynthesis and Cell Cycling. Int J Cancer Res Mol Mech3(1): doi http://dx.doi.org/10.16966/2381-3318.133 Lawrence M Agius, Former Member of Mater Dei Hospital, 27 Ballarat, Guzeppe Caruana Street, Tal-Virtu, Rabat, Rbt09, Republic of Malta, Tel: 356-21451752; E-mail:lawrence.agius@um.edu.mt Adobe PDF Library 10.0.1 False endstream endobj 319 0 obj <> endobj xref 0 1076 0000000000 65535 f 0000196394 00000 n 0000196835 00000 n 0000196859 00000 n 0000206211 00000 n 0000206270 00000 n 0000206726 00000 n 0000207016 00000 n 0000207150 00000 n 0000216007 00000 n 0000216091 00000 n 0000216151 00000 n 0000216595 00000 n 0000217284 00000 n 0000217420 00000 n 0000223875 00000 n 0000239197 00000 n 0000239451 00000 n 0000239825 00000 n 0000239910 00000 n 0000239970 00000 n 0000240121 00000 n 0000240206 00000 n 0000240819 00000 n 0000241182 00000 n 0000241519 00000 n 0000242812 00000 n 0000258285 00000 n 0000258362 00000 n 0000258399 00000 n 0000262654 00000 n 0000263025 00000 n 0000263151 00000 n 0000263502 00000 n 0000263529 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Synthetic Lethality and especially ViabilityPathways in Carcinogenesis within ContextuallyActive DNA Synthesis and Cell Cycling It is proposed that synthetic lethality, whereby the cell life-span is terminated by the appearance of a second modulated gene deletion/mutation, is a governing series of mechanisms that operates to induce, in alternative ways, the emergence of a series of potential carcinogenetic pathways implicating processes of aberrant homologous recombination repair. The stalling of replication forks is symptomatic of mechanistic pathways that significantly induce the creation and progression of double strand breaks inherent to physiologic meiotic pathways. It is further to the disruption of pathways of double strand break repair that the DNA synthesis and cell cycling events further establish the importance of aberrant genetic diversity in tumorigenesis and progression. Synthetic viability, in contrast to synthetic lethality, may potentially aid in the understanding of several steps in the malignant transformation process. It would appear necessary to associate synthetic viability with an essential contrasting process of synthetic lethality, although up to date synthetic viability has been insufficiently emphasized in the discussions regarding the mechanics of carcinogenesis. © 2017 Agius LM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Lawrence M Agius* Homologous recombination Synthetic lethality Carcinogenesis DNA synthesis Cell cycling 2017-04-12T16:45:28+05:30 2017-04-12T16:45:34+05:30 2017-04-12T16:45:34+05:30 4 Adobe InDesign CS6 (Windows) uuid:ec00cf52-1e6e-42df-9a2c-32bafee68c2e xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:16B8B650711FE7118F62BAC458F0A393 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2017-04-12T16:45:28+05:30 xmp.iid:15B8B650711FE7118F62BAC458F0A393 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Citation: Agius LM (2017) Physiologically AberrantHomologous Recombination Coupled to SyntheticLethality and especially Viability Pathways inCarcinogenesis within Contextually Active DNASynthesis and Cell Cycling. Int J Cancer Res Mol Mech3(1): doi http://dx.doi.org/10.16966/2381-3318.133 Lawrence M Agius, Former Member of Mater Dei Hospital, 27 Ballarat, Guzeppe Caruana Street, Tal-Virtu, Rabat, Rbt09, Republic of Malta, Tel: 356-21451752; E-mail:lawrence.agius@um.edu.mt Adobe PDF Library 10.0.1 False endstream endobj 319 0 obj <> endobj 1077 0 obj <>/Metadata 318 0 R/Names 1078 0 R/Outlines 275 0 R/PageMode/UseOutlines/Pages 317 0 R/StructTreeRoot 320 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 318 2 0000340417 00000 n 0000348286 00000 n 1077 1 0000349898 00000 n trailer <<663507AAF899564D930271784FA0E114>]/Prev 116>> startxref 350102 %%EOF