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L*HKq^ybD,o , `:kXD<s^"[y_X01X |`Ww!-%AqZpO`x5fآ;3DKf8h1s6;zOO"1͟YOF49iNsӜ49'*(vbN8܉ v¢N y:n'JL:9N*5^1^Ebx8dQ:1f'1ItОE3F/#e2Xd?:ُN+* %J&F4 Fb)01.qȧ5!I#n$<'0ǓL!i5h% hO#Ȟ5!$-ǀhZW 4 0sF4 iiHKSX  hFC~BR<0+"6NV{<)!H" $8bӼ.iX'{#$N+"^Ize#H8dIb&"ሄĀ|BOO#l8G\ ݑG~qd;02Vމtw_{Н~V9'QӜjz;GiN-8>V1)WQUQUX%BV.(q*++7?[?[?[532)^+^+!KPM%PB %PB %Q{!>Ws%>W3%T1bI%&IܗF%}Ko_ ܗ4&gL~/KoR[RdIL 2ZѢe(E-hQvglwvglwvglwvglwvglwvg qqqq˸į,11Y,011c1c19E/ #Ű-m1la[,_N+2888*sZeN0Doj56a klXcXFذƆ5S\40t'sӜ4E"a/#A a/ap>ă '!p6  0K`xg xB)O,8̂,8̂,8̂,8̂,8̂,8̂,8̂,8BCp^ZpZ"I.\h\h\h\GE(p \$ \( tFtZGGp[pJJ eBPFPF S0E0JEtttF(Jg$Jg5JURRj_E}}I(QBbX$Ծ/cy%-h EK(ZqP%> endobj 638 0 obj <> endobj 639 0 obj <>stream application/pdf Pathogenesis and Therapeutic Targets ofCholangiocarcinoma Cholangiocarcinoma is a lethal cancer of biliary epithelium with variable incidence rates across the world. Given patients often have advanced disease at the time of diagnosis and limited therapeutic options, the prognosis of patients with cholangiocarcinoma remains poor. There are efforts to develop new treatments for cholangiocarcinoma as current standard chemotherapy is with limited benefit. In vitro and in vivo models of cholangiocarcinoma have been studied to unveil underlying molecular mechanisms of cholangiocarcinogenesis. Recent advances in understanding of different pathways underlying cholangiocarcinogenesis will guide the development of potential therapeutic molecular targets. We will do a detailed review of the pathogenesis of cholangiocarcinoma and its relevance in molecular targets for potential therapies for cholangiocarcinoma. Clinical trials using targeted therapies and proposal for potential clinical trials using novel targets will be discussed. © 2015 Park E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Elizabeth Park and Jennifer Wu 2015-10-15T18:44:53+05:30 2015-10-15T18:44:54+05:30 2015-10-15T18:44:54+05:30 Adobe InDesign CS6 (Windows) uuid:707a823a-9537-4103-9c72-fb1bf6bf07f2 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:7BA6788E3E73E5118D57B04779080DCB proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-10-15T18:44:53+05:30 xmp.iid:7AA6788E3E73E5118D57B04779080DCB xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Park E, Wu J (2015) Pathogenesis andTherapeutic Targets of Cholangiocarcinoma. Int JCancer Res Mol Mech, Volume 1(2): doi http://dx.doi.org/10.16966/ijcrmm.109 Jennifer Wu, Division of Hematology and Oncology, Department ofMedicine, NYU School of Medicine, Perlmutter Cancer Center, 550 First Ave, BCD 556, BellevueHospital, New York, NY 10016, USA, E-mail: jennifer.wu@nyumc.org Adobe PDF Library 10.0.1 False endstream endobj 640 0 obj <> endobj xref 0 2124 0000000000 65535 f 0000266682 00000 n 0000267137 00000 n 0000267168 00000 n 0000277371 00000 n 0000277430 00000 n 0000277886 00000 n 0000277915 00000 n 0000278050 00000 n 0000278182 00000 n 0000287720 00000 n 0000287805 00000 n 0000287890 00000 n 0000287950 00000 n 0000288493 00000 n 0000288720 00000 n 0000288856 00000 n 0000288989 00000 n 0000300352 00000 n 0000300466 00000 n 0000317867 00000 n 0000318121 00000 n 0000357536 00000 n 0000357812 00000 n 0000381447 00000 n 0000381734 00000 n 0000388559 00000 n 0000388596 00000 n 0000388681 00000 n 0000388766 00000 n 0000388826 00000 n 0000389271 00000 n 0000390295 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Cholangiocarcinoma is a lethal cancer of biliary epithelium with variable incidence rates across the world. Given patients often have advanced disease at the time of diagnosis and limited therapeutic options, the prognosis of patients with cholangiocarcinoma remains poor. There are efforts to develop new treatments for cholangiocarcinoma as current standard chemotherapy is with limited benefit. In vitro and in vivo models of cholangiocarcinoma have been studied to unveil underlying molecular mechanisms of cholangiocarcinogenesis. Recent advances in understanding of different pathways underlying cholangiocarcinogenesis will guide the development of potential therapeutic molecular targets. We will do a detailed review of the pathogenesis of cholangiocarcinoma and its relevance in molecular targets for potential therapies for cholangiocarcinoma. Clinical trials using targeted therapies and proposal for potential clinical trials using novel targets will be discussed. © 2015 Park E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Elizabeth Park and Jennifer Wu 2015-10-15T18:44:53+05:30 2015-10-15T18:45:07+05:30 2015-10-15T18:45:07+05:30 Adobe InDesign CS6 (Windows) uuid:dda3aca4-735c-4bd7-8d73-690c0c2388df xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:7BA6788E3E73E5118D57B04779080DCB proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-10-15T18:44:53+05:30 xmp.iid:7AA6788E3E73E5118D57B04779080DCB xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Park E, Wu J (2015) Pathogenesis andTherapeutic Targets of Cholangiocarcinoma. Int JCancer Res Mol Mech, Volume 1(2): doi http://dx.doi.org/10.16966/ijcrmm.109 Jennifer Wu, Division of Hematology and Oncology, Department ofMedicine, NYU School of Medicine, Perlmutter Cancer Center, 550 First Ave, BCD 556, BellevueHospital, New York, NY 10016, USA, E-mail: jennifer.wu@nyumc.org Adobe PDF Library 10.0.1 False endstream endobj 640 0 obj <> endobj 2125 0 obj <>/Metadata 639 0 R/Names 2126 0 R/Outlines 591 0 R/PageMode/UseOutlines/Pages 638 0 R/StructTreeRoot 641 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 639 2 0000610435 00000 n 0000617512 00000 n 2125 1 0000618797 00000 n trailer <<56BAA4652C025042A85C84723960DFA1>]/Prev 116>> startxref 619001 %%EOF