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QD%l/'HTexM«'ߣ1jO_+n> |8DXERTYݷ]hYvifa3'1oҏavّ'ӧ}ԱjֱF3 ]Gu]GunGg` v`vLrGuT^ztXvlaunG}=NswLrO=c;Fc;ֱ#;{Y~[1ѽ!!І mІ[FAsjZ%ɄDV E;-x ؂ !b %܂񀺠-xdQDbgIν}3$<*j̣\/:8=0?[H8 a~÷g680 I=co47c\G6b_Fp2dނMT5q)'7ނmDULKK& '/l!yDn쬛wM SKqTMRUpTMRmӣXhW}z Uz+V+SϾk*Wȭ:+:+*WgE3 =YMSN GWp )ՖS[F_7iv' !6L0#O?a2&sXaP2  K0, K0,;M0㜮~gRwu;zw`v}N?Nik1ֹHRvNunp޺Qw t薻8ln\OOOQc;z9-֩჊4W&Ҝ2VCjXڜ)ٜm~xNlSC~jTy!5s/e6V܊[qs+n{k ysoA2hCmȠRbk|׾_r5~SYߒ +vWkXk_ }'/_L6 kz| _I׆ڈ/_$~ r[=п6r{))){8 ¶Mи 7&c`lbM7&T؄ PamyYP 6A&(Ef;Dfl›Mx o6vrj*ǖXX;i$IH&!0/ҿH>>ujaaZ:͋F8Iè\Vu).,V ٌ\1IHEn-Ix[`T#Z$:II<-hD$^#Q,.>"HLGb:HD:$!qHF52{^F4S__GkӲ# t endstream endobj 765 0 obj <> endobj 766 0 obj <> endobj 767 0 obj <>stream application/pdf Microbiome Analysis: Trends in Cancer Epidemiology, Challenges and Opportunities Elizabeth F Hebert Rao L Divi and Mukesh Verma* Analysis of microbiome sampled from a given cancer site can yield information that may serve as a prognostic of exposure, risk, disease progression, and treatment response. We reviewed available published literature, and grants funded by the National Cancer Institute’s Division of Cancer Control and Population Sciences to identify trends and areas for future research. The incorporation of microbiome analysis in epidemiologic studies of cancer is providing some promising insights into risk stratification. However, our analysis identified several knowledge gaps in this emerging field: 1. Limited evidence for the stability of different biospecimen types over time and at given temperatures for microbiome analysis, 2. Analysis software that reliably standardizes sequencing data from different platforms and corrects for biases against rare or unrepresented taxa, 3. Harmonization of methods used for microbiome analysis across research centers. 4. Surrogate markers that will be useful for monitoring disease progression from the time of infection to cancer development, 5. Time-varying microbiome in the natural history of different cancers in order to identify key microbiota or shifts in community structure, and 6. Determining whether the microbiota cause or effect cancer risk and outcomes. If these knowledge gaps are addressed, microbiome analysis is likely to provide the cancer field with new approaches for early diagnosis and help develop more effective preventative measures. Microbiome Microbiota Cancer Epidemiology ©2015 Verma M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2016-07-25T16:29:21+05:30 2016-07-25T16:29:22+05:30 2016-07-25T16:29:22+05:30 Adobe InDesign CS6 (Windows) uuid:572cdc5a-76f1-46cc-a9a3-1aae1f6d110f xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:4B7416D75652E611B951B1C8516E4B81 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-07-25T16:29:21+05:30 xmp.iid:BB7403C65652E611B951B1C8516E4B81 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Hebert E, Rao LD, Verma M (2015) Microbiome Analysis: Trends in Cancer Epidemiology, Challenges and Opportunities. Int J Cancer Res Mol Mech, Volume1.1: http://dx.doi.org/10.16966/ijcrmm.101 Mukesh Verma, Ph.D. Chief, Methods and Technologies Branch, Program Director, Epidemiology and Genomics Research Program,Division of Cancer Control and Population Sciences, National Cancer Institute (NCI), National Institutes of Health (NIH), Suite# 4E102. 9609 Medical Center Drive, Rockville, MD 20850, USA, Phone (240) 276-6889 ; Fax (240) 276-7909 ; E-mail: vermam@mail.nih.gov Adobe PDF Library 10.0.1 False endstream endobj 768 0 obj <> endobj xref 0 2483 0000000000 65535 f 0000248659 00000 n 0000249139 00000 n 0000249163 00000 n 0000258792 00000 n 0000258851 00000 n 0000259463 00000 n 0000259486 00000 n 0000259621 00000 n 0000266294 00000 n 0000302306 00000 n 0000302342 00000 n 0000338356 00000 n 0000338393 00000 n 0000338469 00000 n 0000338745 00000 n 0000338821 00000 n 0000339097 00000 n 0000373992 00000 n 0000407719 00000 n 0000407804 00000 n 0000407864 00000 n 0000408422 00000 n 0000408919 00000 n 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0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF 767 0 obj <>stream application/pdf Microbiome Analysis: Trends in Cancer Epidemiology, Challenges and Opportunities Elizabeth F Hebert Rao L Divi and Mukesh Verma* Analysis of microbiome sampled from a given cancer site can yield information that may serve as a prognostic of exposure, risk, disease progression, and treatment response. We reviewed available published literature, and grants funded by the National Cancer Institute’s Division of Cancer Control and Population Sciences to identify trends and areas for future research. The incorporation of microbiome analysis in epidemiologic studies of cancer is providing some promising insights into risk stratification. However, our analysis identified several knowledge gaps in this emerging field: 1. Limited evidence for the stability of different biospecimen types over time and at given temperatures for microbiome analysis, 2. Analysis software that reliably standardizes sequencing data from different platforms and corrects for biases against rare or unrepresented taxa, 3. Harmonization of methods used for microbiome analysis across research centers. 4. Surrogate markers that will be useful for monitoring disease progression from the time of infection to cancer development, 5. Time-varying microbiome in the natural history of different cancers in order to identify key microbiota or shifts in community structure, and 6. Determining whether the microbiota cause or effect cancer risk and outcomes. If these knowledge gaps are addressed, microbiome analysis is likely to provide the cancer field with new approaches for early diagnosis and help develop more effective preventative measures. Microbiome Microbiota Cancer Epidemiology ©2015 Verma M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2016-07-25T16:29:21+05:30 2016-07-25T16:29:26+05:30 2016-07-25T16:29:26+05:30 Adobe InDesign CS6 (Windows) uuid:9718c970-f85d-4324-883f-3135420c256a xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:4B7416D75652E611B951B1C8516E4B81 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-07-25T16:29:21+05:30 xmp.iid:BB7403C65652E611B951B1C8516E4B81 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Hebert E, Rao LD, Verma M (2015) Microbiome Analysis: Trends in Cancer Epidemiology, Challenges and Opportunities. Int J Cancer Res Mol Mech, Volume1.1: http://dx.doi.org/10.16966/ijcrmm.101 Mukesh Verma, Ph.D. Chief, Methods and Technologies Branch, Program Director, Epidemiology and Genomics Research Program,Division of Cancer Control and Population Sciences, National Cancer Institute (NCI), National Institutes of Health (NIH), Suite# 4E102. 9609 Medical Center Drive, Rockville, MD 20850, USA, Phone (240) 276-6889 ; Fax (240) 276-7909 ; E-mail: vermam@mail.nih.gov Adobe PDF Library 10.0.1 False endstream endobj 768 0 obj <> endobj 2484 0 obj <>/Metadata 767 0 R/Names 2485 0 R/Outlines 714 0 R/PageMode/UseOutlines/Pages 766 0 R/StructTreeRoot 769 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 767 2 0000750012 00000 n 0000758118 00000 n 2484 1 0000759930 00000 n trailer <<7DD23D560C3EEC419D44E1EE1E89BB7F>]/Prev 116>> startxref 760134 %%EOF